All Posts

A new study from the Rizzoli Orthopedic Institute (Life Sciences, 2025) takes a closer look at 𝘃𝗲𝗿𝘁𝗲𝗯𝗿𝗮𝗹 𝗯𝗼𝗻𝗲 𝗺𝗮𝗿𝗿𝗼𝘄 𝗮𝘀𝗽𝗶𝗿𝗮𝘁𝗲 (𝘃𝗕𝗠𝗔) 𝗰𝗹𝗼𝘁𝘀 harvested during pedicle screw prep. While this is not a comparative trial, the findings raise several interesting possibilities for spine surgeons to consider. 𝟭. 𝗩𝗲𝗿𝘁𝗲𝗯𝗿𝗮𝗹 𝗺𝗮𝗿𝗿𝗼𝘄 𝗮𝘀 𝗮𝗻 𝘂𝗻𝗱𝗲𝗿𝘂𝘀𝗲𝗱 𝗯𝗶𝗼𝗹𝗼𝗴𝗶𝗰 𝘀𝗼𝘂𝗿𝗰𝗲 The authors harvested marrow directly from the ve

If you’ve been around orthobiologics, you’ve heard of 𝗜𝗥𝗔𝗣 — 𝗜𝗻𝘁𝗲𝗿𝗹𝗲𝘂𝗸𝗶𝗻-𝟭 𝗥𝗲𝗰𝗲𝗽𝘁𝗼𝗿 𝗔𝗻𝘁𝗮𝗴𝗼𝗻𝗶𝘀𝘁 𝗣𝗿𝗼𝘁𝗲𝗶𝗻. Its job: block 𝗜𝗟-𝟭, the cytokine that drives joint inflammation and cartilage loss. When IL-1 is blocked by 𝗜𝗟-𝟭𝗥𝗮, inflammation cools — often dramatically. 𝗪𝗵𝗲𝗿𝗲 𝗜𝘁 𝗦𝘁𝗮𝗿𝘁𝗲𝗱 In the early 2000s, 𝗗𝗿. 𝗣𝗲𝘁𝗲𝗿 𝗪𝗲𝗵𝗹𝗶𝗻𝗴 (Germany) discovered that incubating blood with treated glass beads triggered white ce

Ten pages of warning letters dropped this week, possibly a record. Most came from CDER under the headline: "Unlawful Sale of Unapproved and Misbranded Drugs to U.S. Consumers Over the Internet." 𝗜 𝗱𝗶𝗱𝗻'𝘁 𝗮𝗻𝗮𝗹𝘆𝘇𝗲 𝘁𝗵𝗲𝗺 𝗮𝗹𝗹, 𝗯𝘂𝘁 𝗺𝗼𝘀𝘁 𝗹𝗲𝘁𝘁𝗲𝗿𝘀 𝘀𝗲𝗲𝗺 𝘁𝗼 𝗯𝗲 𝗯𝗮𝘀𝗲𝗱 𝗼𝗻 𝗙𝗗𝗔’𝘀 𝗿𝗲𝘃𝗶𝗲𝘄 𝗼𝗳 𝗰𝗼𝗺𝗽𝗮𝗻𝘆 𝘄𝗲𝗯𝘀𝗶𝘁𝗲𝘀. 𝗧𝗵𝗲 𝗺𝗮𝗶𝗻 𝗽𝗮𝘁𝘁𝗲𝗿𝗻 𝘀𝗲𝗲𝗺𝘀 𝗰𝗹𝗲𝗮𝗿: -Online compounding pharmacies promoting compounded GLP-1